KMID : 0853020130160010050
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Journal of Korean Burn Society 2013 Volume.16 No. 1 p.50 ~ p.53
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Clinical Efficacy of Pre-operative 18F-FDG-PET/ CT in Marjolin¡¯s Ulcer
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Rhee Byung-Jun
Ko Jang-Hyu Hur Gi-Yeun Seo Dong-Kook Lee Jong-Wook Choi Jai-Koo Jang Young-Chul
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Abstract
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Purpose: Marjolin¡¯s ulcer is a rare malignancy that occur in chronic wounds or scars. Marjolin¡¯s ulcers tend to infiltrate adjacent tissue more extensively than squamous cell carcinoma that occurs in normal skin, and it is prone to recurrence and metastases, leading to a poor prognosis. Hence, its accurate diagnosis and treatment is very important. The aim of this study was to investigate the diagnostic value and clinical efficacy of preoperative 18F-FDG-PET/CT. Methods: The study population consisted of 27 patients who were suspected to have Marjolin¡¯s ulcer who visited this hospital between January 2009 and June 2012, and who had also received preoperative PET/CT. To confirm the diagnostic efficacy of preoperative PET/CT, the PET/CT findings of the primary lesion and the lymph node, as well as the postoperative histology results were compared to investigate the sensitivity, specificity, false-positive and false-negative rates. Results: The sensitivity and the specificity for the primary lesion of the Marjolin¡¯s ulcer in the preoperative PET/CT were 93.3% and 100% respectively. The false-positive rate and the false-negative rate here were 0% and 6.7% respectively. The sensitivity and the specificity for the lymph node metastases of the Marjolin¡¯s ulcer in the preoperative PET/CT were 100% and 66.7% respectively. The false-positive rate and the false-negative rate here were 33.3% and 0% respectively. The histological results of Marjolin¡¯s ulcer showed that 14 patients had squamous cell carcinoma and 1 had sarcoma. Conclusion: Preoperative PET/CT used for the assessment of Marjolin¡¯s ulcer and its primary lesion showed a high level of sensitivity and specificity. It was also useful because it allowed the assessment of the primary lesion, lymph node metastases, and distant metastases with a single test. However, the specificity for lymph node metastases was relatively lower, and more research would be needed to improve this.
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KEYWORD
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Marjolin¡¯s ulcer, Positron-emission tomography and computed tomography
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